Entresto (Sacubitril/Valsartan)

What is Entresto (Sacubitril)?

Entresto is a prescription medication used to treat the symptoms of congestive heart failure. Entresto belongs to the Angiotensin Receptor-Neprilysin Inhibitors (ARNi); ARBs; Neprilysin Inhibitors class of medicines. Entresto can be taken alone or in combination with other drugs.

What is Entresto (Sacubitril) used for?

Entresto is prescribed to persons who have persistent heart failure. This medication reduces the likelihood of needing to be hospitalized if symptoms worsen, as well as the chance of mortality from heart failure.

How does Entresto (Sacubitril) work?

Entresto contains the drugs sacubitril and valsartan. Sacubitril is an antihypertensive medication. Valsartan works by blocking the angiotensin II receptor (sometimes called an ARB). Sacubitril works by boosting the quantities of proteins in the body that have the ability to dilate (widen) blood arteries. This lowers blood pressure by lowering salt levels. Valsartan prevents blood vessels from constricting, lowering blood pressure and improving blood flow.

Direction for Use:

How to take Entresto (Sacubitril)?

This is an oral pill that is taken with or without food. Avoid crushing, chewing, smashing, or opening the capsule; instead, consume it whole. It is normally recommended that you take this medication exactly as directed by your doctor. It is often advised to take it twice a day with some water.

What is the different dosage available for Entresto (Sacubitril)?

The dosage is offered as an oral tablet of 24mg/26mg, 49mg/51mg, and 97mg/103mg depending on the line of treatment chosen.

What is the recommended dosage for Entresto?

The recommended initial dose for Entresto is 49/51 mg twice daily orally. After 2 to 4 weeks, increase the dose of Entresto to the maintenance dose of 97/103 mg twice daily, as tolerated by the patient.

What if you forget to give a dose of Entresto?

Get the missed dose as soon as you recall. If the next dose is approaching, skip the missed dose and resume your usual dosing schedule.

Precautions for Entresto (Sacubitril):

• If you are allergic to sacubitril, valsartan (Diovan), or if you've ever experienced a severe allergic reaction to a blood pressure medication such as an ACE inhibitor or an ARB, you shouldn't take Entresto. If you have kidney illness, you may also need to avoid taking Entresto with aliskiren.

• Inform your doctor if you have ever experienced liver disease, diabetes, hereditary angioedema, are on a low-salt diet, or are dehydrated to ensure that Entresto is safe for you.

• If you are pregnant, do not use Entresto. If you become pregnant, stop using it and consult your doctor right away. The risk to the unborn child may suffer harm or perhaps die.

Side-Effects of Entresto (Sacubitril):

Common side effects of Entresto include:

• Kidney issues

• High potassium

• Feeling lightheaded or dizzy

• Coughing

If you have more severe symptoms like as mentioned below seek emergency medical attention:

• An allergic response to Entresto like hives

• Breathing issues

• Facial, lip, tongue, or throat swelling

• Extreme Exhaustion

• Slow heartbeat, Weak pulse

• Weak muscles, Tingling sensations

• Painful or difficult urination

• Ankle or foot edema

• Feeling out of breath

Interaction with Entresto:

Entresto ( Sacubitril/ Valsartan) shows interactions with drugs like lithium, aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and other NSAIDs. It should also be avoided while using any other heart or blood pressure medications; diuretics, "water pills;" potassium-containing medications, or dietary supplements.

Storage:

Entresto (Sacubitril) should be kept at room temperature (15-30 degrees) and away from light, heat, moisture, and children's access.

Other Important Information:

• The Medication should not be used without a doctor’s prescription.

• Use of Entresto in conjunction with any aliskiren-containing drug is not recommended if you have diabetes (Tekturna, Tekamlo).

• When taking Entresto, you should wait 36 hours after taking any ACE inhibitor prescription.

• If you are pregnant, do not use Entresto. If you become pregnant, stop using it and call your doctor right away.

• Before you drive, operate machinery, or engage in any other activity that could be hazardous if you become dizzy from this medication, be sure to know how you respond to it.

Is It Safe To Buy Entresto From an Online Pharmacy?

If you are looking to buy Entresto or any prescription drugs from an in the USA then you can order from a safe and accredited International pharmacy like MedsEngage, which contracts with Canadian Pharmacy and pharmacy in India. You require a valid prescription for your prescription drugs.

FAQs:

What is the heart-health benefit of Entresto?

Entresto eases cardiac strain while relaxing blood arteries and enhancing blood flow. Sacubitril, an inhibitor of neprilysin, and valsartan, an ARB, are both present in the combination drug Entresto. It aids in enhancing your heart's capacity to circulate blood throughout your body.

What time of day should you take Entresto?

One tablet in the morning and one in the evening should be taken. Take the entire pill of Entresto. You can take Entresto with or without food. Entresto needs to be taken consistently each day at the same time.

How long does Entresto take to start working?

Entresto levels peak between 30 minutes and two hours. It may take two weeks to reach steady levels. Before changing the dose, your healthcare professional might wait around two weeks.

Is drinking alcohol compatible with Entresto?

While using Entresto, avoid using potassium supplements or salt replacements unless your doctor has specifically instructed you to. Alcohol use can further reduce blood pressure and may exacerbate some of Entresto's negative effects.

Can Entresto make you feel breathless?

Breathlessness, however, may indicate a serious allergic reaction after using Entresto. Angioedema is one of these reactions. Breathlessness is another symptom of severe side effects of the medication. One should immediately consult the doctor.

References:

• https://www.drugs.com/entresto.html
• https://www.mayoclinic.org/drugs-supplements/sacubitril-and-valsartan-oral-route/description/drg-20150920