Esbriet (Pirfenidone)

What is Esbriet?

Esbriet, also known by its generic name Pirfenidone, is an oral medication used for the treatment of idiopathic pulmonary fibrosis (IPF). IPF is a progressive and potentially fatal lung disease characterized by the scarring (fibrosis) of lung tissue for unknown reasons. This scarring makes the lungs stiff, resulting in difficulty breathing and impaired lung function over time.

Clinical trials have demonstrated Esbriet's efficacy in reducing the decline in lung function associated with IPF. Patients treated with Esbriet have shown slower rates of decline in forced vital capacity (FVC), a key measure of lung function, compared to those receiving a placebo. Additionally, Esbriet has been associated with a reduced risk of acute exacerbations, which are sudden and severe worsening of symptoms that can lead to hospitalization or death in IPF patients.

How to Use Esbriet?

1. Prescription and Dosage:
• Esbriet is available by prescription only and should be obtained from a licensed healthcare provider. Your healthcare provider will determine the appropriate dosage of Esbriet based on factors such as your age, weight, kidney function, and other medications you may be taking.
• Follow your healthcare provider's instructions regarding the dosage and frequency of Esbriet administration.
2. Administration:
• Esbriet is taken orally in the form of capsules.
• Swallow the capsules whole with water, and take them with food.
• Do not crush, chew, or break the capsules before swallowing.
3. Timing:
• Typically, Esbriet is taken three times a day, with approximately 6 hours between doses.
• If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
4. Monitoring and Follow-Up:
• Your healthcare provider may monitor your lung function and overall health regularly while you are taking Esbriet.
• Attend all scheduled follow-up appointments with your healthcare provider to assess your response to treatment and address any concerns or side effects.

What is Esbriet used for?

Esbriet (Pirfenidone) is primarily used for the treatment of idiopathic pulmonary fibrosis (IPF).

The goals of treatment with Esbriet in IPF patients include:

• Slowing Disease Progression: Esbriet has been shown to slow the decline in lung function associated with IPF, as measured by forced vital capacity (FVC), which is a key indicator of lung function.
• Reducing Exacerbation Risk: Esbriet may also reduce the risk of acute exacerbations, which are sudden and severe worsening of symptoms that can lead to hospitalization or death in IPF patients.
• Improving Quality of Life: By slowing disease progression and reducing exacerbation risk, Esbriet may help improve the quality of life for individuals living with IPF, allowing them to maintain better lung function and experience fewer respiratory symptoms.

What are the Side Effects of Esbriet?

Esbriet (Pirfenidone) is generally well-tolerated by most patients, but like any medication, it can cause Side Effects in some individuals.

Here is a list of potential Side Effects associated with Esbriet:

• Nausea
• Diarrhoea
• Abdominal Discomfort
• Skin Rash
• Sensitivity to Sunlight
• Fatigue
• Loss of Appetite
• Weight Loss
• Headache
• Liver Function Abnormalities
• Dizziness
• Respiratory Symptoms

What are the Safety/Warnings for Esbriet?

Before starting treatment with Esbriet (Pirfenidone), it's essential to be aware of certain safety considerations and warnings associated with the medication.

Here are some important points to keep in mind:

• Liver Function: Esbriet may cause abnormalities in liver function tests. Healthcare providers may monitor liver function before initiating treatment and periodically during treatment. Patients should promptly report any symptoms of liver problems, such as jaundice (yellowing of the skin or eyes), dark urine, or persistent abdominal pain.
• Photosensitivity: Esbriet can increase sensitivity to sunlight or artificial UV rays.
• Gastrointestinal Effects: Esbriet commonly causes gastrointestinal side effects, such as nausea, diarrhea, and abdominal discomfort.
• Respiratory Symptoms: In some cases, Esbriet may worsen respiratory symptoms such as cough or shortness of breath. Patients should notify their healthcare provider if they experience any worsening of respiratory symptoms while taking Esbriet.
• Drug Interactions: Esbriet may interact with other medications, supplements, or herbal products. Patients should inform their healthcare provider about all medications they are taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements, to avoid potential interactions.
• Pregnancy and Breastfeeding: The safety of Esbriet during pregnancy and breastfeeding is not well-established.
• Hepatic Impairment: Esbriet should be used with caution in patients with mild to moderate hepatic impairment. Close monitoring of liver function is recommended in these patients.
• Renal Impairment: Esbriet should be used with caution in patients with severe renal impairment or end-stage renal disease requiring dialysis. Dosage adjustment may be necessary in these patients.

What are the Esbriet Interactions?

Here are some potential drug interactions to be aware of:

• CYP1A2 Substrates: Esbriet may inhibit the activity of cytochrome P450 (CYP) 1A2 enzymes, which are involved in the metabolism of certain medications. Drugs metabolized by CYP1A2, such as theophylline and caffeine, may have increased levels and prolonged effects when taken concomitantly with Esbriet.
• CYP2C9 Substrates: Esbriet may also inhibit CYP2C9 enzymes, which metabolize certain medications. Drugs metabolized by CYP2C9, such as warfarin, phenytoin, and nonsteroidal anti-inflammatory drugs (NSAIDs), may have increased levels and potential for toxicity when taken with Esbriet.
• CYP2C19 Substrates: Esbriet may inhibit CYP2C19 enzymes, affecting the metabolism of medications such as proton pump inhibitors (e.g., omeprazole, esomeprazole) and certain antidepressants (e.g., citalopram, escitalopram).
• CYP2D6 Substrates: Esbriet may inhibit CYP2D6 enzymes, which metabolize certain medications, including some antidepressants, antipsychotics, and opioids. Concomitant use of Esbriet with these medications may increase their plasma concentrations and potential for adverse effects.
• CYP3A4 Substrates: Esbriet may inhibit CYP3A4 enzymes, affecting the metabolism of medications such as simvastatin, atorvastatin, and certain immuno-suppressants (e.g., cyclosporine, tacrolimus).
• P-glycoprotein Substrates: Esbriet may inhibit P-glycoprotein (P-gp), a transporter protein involved in the absorption and distribution of various medications. Concomitant use of Esbriet with P-gp substrates, such as digoxin and certain anticoagulants (e.g., dabigatran), may increase their plasma concentrations and potential for toxicity.
• CYP Enzyme Inducers/Inhibitors: Drugs that induce or inhibit CYP enzymes may affect the metabolism of Esbriet and alter its plasma concentrations. Examples include rifampin (CYP inducer) and ketoconazole (CYP inhibitor).
• Alcohol: While specific interactions between Esbriet and alcohol have not been extensively studied, alcohol consumption may exacerbate certain side effects of Esbriet, such as gastrointestinal symptoms and liver function abnormalities. Patients should limit alcohol intake while taking Esbriet.

What are the Dosages of Esbriet?

Esbriet (Pirfenidone) is available in different dosages to accommodate individual patient needs and treatment plans.

1. Capsule:
• 267mg (Esbriet, generic)
2. Tablet:
• 267 mg (Esbriet, generic)
• 801 mg (Esbriet, generic)

Esbriet Storage:

• Room Temperature: Esbriet capsules should be stored at room temperature, ideally between 20°C to 25°C (68°F to 77°F). Avoid exposure to excessive heat or cold, as well as direct sunlight.
• Dry Environment: Store Esbriet in a dry place away from moisture. Avoid storing the medication in bathrooms or other areas with high humidity.
• Original Container: Keep Esbriet capsules in their original container with the lid tightly closed. The container helps protect the medication from light and moisture.
• Childproof Packaging: Ensure that the container is child-resistant and kept out of reach of children and pets. Esbriet should be stored in a secure location to prevent accidental ingestion.
• Avoid Pill Dispensers: Esbriet capsules should not be transferred to pill dispensers or other storage containers unless specifically instructed by a healthcare professional. Keeping the medication in its original container helps maintain its integrity and prevents contamination.
• Check Expiry Date: Before taking Esbriet, check the expiration date on the container. Do not use expired medication, as it may not be as effective or safe.
• Travel Considerations: If traveling with Esbriet, ensure that the medication is stored in a cool, dry place and protected from extreme temperatures. Consider using a travel cooler or insulated bag if necessary.

Is it safe to buy Esbriet online from an Online Pharmacy?

Here are some considerations to keep in mind when purchasing medication from an online pharmacy:

• Legitimacy and Reputation: Only purchase medication from reputable and licensed online pharmacies. Look for pharmacies that display a valid pharmacy license and contact information, including a physical address and phone number. Check online reviews and ratings to assess the reputation of the pharmacy. (Check Meds Engage Pharmacy).
• Verification of Medication: Ensure that the medication being sold by the online pharmacy is genuine and approved by regulatory authorities. Be cautious of counterfeit or substandard medications, especially when purchasing prescription drugs.
• Prescription Requirements: Many medications, especially prescription drugs, require a valid prescription from a licensed healthcare provider. Beware of online pharmacies that offer prescription medication without requiring a prescription or offering to provide a prescription based on an online questionnaire without a consultation with a healthcare professional.
• Quality Assurance: Legitimate online pharmacies adhere to quality assurance standards and regulations to ensure the safety and efficacy of the medication.
• Privacy and Security: Choose online pharmacies that prioritize patient privacy and data security. Ensure that the website uses secure encryption protocols for transmitting personal and financial information and has a privacy policy that outlines how patient information is protected and used.
• Regulatory Compliance: Online pharmacies should comply with relevant laws and regulations governing the sale of medication in your country or region. Check if the online pharmacy is licensed or accredited by regulatory authorities and if it follows guidelines for dispensing medication safely and legally.
• Consultation and Support: Legitimate online pharmacies may offer consultation services with licensed pharmacists or healthcare professionals to answer questions and provide guidance on medication use. Look for pharmacies that offer customer support and assistance with medication inquiries or concerns.
• Price and Payment: Compare prices of medications across different online pharmacies to ensure competitive pricing. Use secure payment methods to protect financial information when making purchases online. One can buy Esbriet Online from Meds Engage Pharmacy to get legit medication at genuine prices.

FAQs:

Why Esbriet Medication is prescribed?

Esbriet represents an important treatment option for individuals with IPF, offering the potential to slow disease progression and improve quality of life. However, like all medications, it may not be suitable for everyone, and patients should work closely with their healthcare providers to determine the most appropriate treatment approach.

How Should Esbriet be used?

Take Esbriet orally as directed by your healthcare provider. The typical starting dosage is 801 mg (three capsules) taken three times daily with food, for a total daily dose of 2403 mg. Your healthcare provider may adjust the dosage based on your response to treatment and any side effects experienced. Swallow the Esbriet capsules whole with water. Do not crush, chew, or break the capsules before swallowing.

What Should I Do if I Forget a Dose of Esbriet?

If you remember that you missed a dose and it is not close to the time of your next scheduled dose, take the missed dose as soon as you remember. Skip the Missed Dose if Close to the Next Dose: If it is almost time for your next scheduled dose, skip the missed dose altogether. Do not double the dose to make up for the missed one. Resume Normal Schedule: Continue taking Esbriet as prescribed by your healthcare provider, following your regular dosing schedule.

What is the best drug for fibrosis in the lungs?

The choice of medication for treating lung fibrosis, particularly idiopathic pulmonary fibrosis (IPF), depends on various factors such as disease severity, patient characteristics, and individual response to treatment. The Esbriet medicine is the best drug for fibrosis.

How does Esbriet improve lung function?

Esbriet inhibits various pathways involved in the formation and progression of fibrosis in the lungs. It may interfere with the synthesis of collagen, a key component of scar tissue, and inhibit the proliferation of fibroblasts, the cells responsible for producing excess collagen in fibrotic tissue. By reducing fibrosis, Esbriet helps preserve lung structure and function.

References:

• https://www.healthline.com/health/drugs/esbriet-dosage#talk-with-your-doctor
• https://www.medicalnewstoday.com/articles/drugs-esbriet-cost