Janumet (Sitagliptin/Metformin)

How Janumet works?

It is composed of a combination of Metformin as well as Sitagliptin, thus it is thought to work by two mechanisms of action:

• Metformin is a biguanide anti-diabetic drug that lowers the sugar which is formed by the liver and which is absorbed in the stomach or intestine.

• Sitagliptin falls under the class of anti-diabetic drugs called dipeptidyl peptidase-4 inhibitors. It is found to act by increasing the amount of insulin and decreasing the amount of glucagon produced by your body, which helps the body to reduce the level of sugar in your blood.

How to use Janumet?

The initial recommended dose is one tablet of Jnaumet three times daily just before each meal. The correct dosage and prescription commonly depend on the patient and the condition being treated. Take Janumet exactly as directed by your doctor. Do not take more or less than instructed by your physician. The overdose of this drug can have dangerous adverse effects like lactic acidosis (excessive accumulation of lactic acid in the body). The symptoms include difficulty breathing, slow heart rate, weakness, fatigue, feeling cold, and muscle pain.

What to do if you miss a dose of Janumet?

If, by chance, you miss out on taking a dose of this tablet, take it as soon as possible. On the other hand, if it is roughly the time for your next dosage, you may omit the dose that you forgot to take. Never take two doses to make up for a skipped one.

Possible Janumet side effects:

Janumet shows side effects such as:

• Loss of appetite

• Sour mouth taste

• Loose stools (diarrhoea)

• Lactic acidosis (too much blood in the blood)

What are the drugs that interact with Janumet?

Janumet interacts with the following drugs and increases or decreases its own potency:

• Anti-epileptic medicines such as Phenytoin.

• Antifungal drugs like Fluconazole.

• NSAIDs such as Ibuprofen.

• Anticoagulants such as Warfarin

• Antibiotics like Trimethoprim, Vancomycin

• Sulfa drugs such as Bactrim

• Diuretics like Furosemide

• Beta blockers like Atenolol

Precautions:

Some safety tips have to be taken while taking this drug:

• Care should be taken in patients with a history of liver and kidney disease, ketoacidosis (ketone bodies in urine), and the elderly.

• Avoid alcohol consumption while taking this medicine.

• Tell your doctor if you are allergic to Metformin, Sitagliptin, or any other drugs of these classes.

• Also, it is contraindicated in pregnant and lactating mothers.

• Patients should be monitored closely for loss of glucose control.

• Janumet must not be given to patients who have the problem of diabetic ketoacidosis (High levels of ketones in the blood).

Is it safe to buy Janumet from an Online Pharmacy?

If you are looking to buy Janumet online or any prescription drugs from an in USA then you can order from a safe and accredited International pharmacy like MedsEngage, which contracts with Canadian Pharmacy and pharmacy in India. You require a valid prescription for your prescription drugs.

FAQs:

What happens if you take too much Janumet?

Taking too much Janumet (a combination of sitagliptin and metformin) can lead to serious side effects. Overdosing on metformin can cause lactic acidosis, a dangerous condition characterized by muscle pain, weakness, trouble breathing, stomach pain, dizziness, and slow or irregular heartbeats. Excessive sitagliptin intake can lead to severe hypoglycemia, especially when combined with other diabetes medications. If an overdose is suspected, seek immediate medical attention to address these potentially life-threatening conditions.

What does Janumet do for diabetes?

Janumet combines two medications, sitagliptin and metformin, to help manage type 2 diabetes. Metformin works by decreasing glucose production in the liver and improving the body's sensitivity to insulin, which helps lower blood sugar levels. Sitagliptin improves incretin hormone levels, which enhance the insulin release and reduce the levels of glucagon after meals. Together, these actions help control blood sugar levels more effectively than either drug alone.

Is Janumet and Metformin the same?

Janumet and metformin are not the same, although Janumet contains metformin as one of its components. Metformin is a single medication used to lower blood glucose levels in type 2 diabetes by decreasing glucose production in the liver and improving insulin sensitivity. Janumet is a combination of two medications, metformin and sitagliptin. Sitagliptin is a DPP-4 inhibitor that works by increasing incretin hormone levels to boost insulin release and reduce glucagon levels, offering a more comprehensive approach to managing blood sugar.

Is Janumet and Januvia the same thing?

Janumet and Januvia are related but not the same. Januvia contains sitagliptin, a DPP-4 inhibitor that increases incretin hormones to help control blood sugar levels by enhancing insulin release and reducing glucagon levels. Janumet combines sitagliptin with metformin, which decreases glucose production in the liver and improves insulin sensitivity. While Januvia targets a single mechanism to manage blood sugar, Janumet provides a dual approach by combining the benefits of both sitagliptin and metformin.

Can Janumet cause cancer?

There is currently no conclusive evidence that Janumet causes cancer. Some studies have explored potential links between diabetes medications, including sitagliptin (found in Janumet), and cancer risk, but results have been inconclusive and often contradictory. The FDA and other regulatory agencies continue to monitor the safety of these medications. It's essential to discuss any concerns about medication risks with your healthcare provider, who can provide personalized advice based on the latest research and your health profile.

References:

• https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022044s035lbl.pdf
• https://www.mayoclinic.org/drugs-supplements/sitagliptin-and-metformin-oral-route/description/drg-20070903